The hysterical tale of Spot (Nathan Lane), a talking canine whose ultimate wish is to become a real boy. When the opportunity presents itself -- through the DNA manipulations of wacko scientist Ivan Krank (voiced by Kelsey Grammer) -- Spot quickly follows his family to Florida in order to make the evolution to human form. However, Dr. Krank's experiments have been far from perfect thus far and, although Spot's transformation to humanity is complete, nobody calculates dog years into the equation.