When the world is in trouble they call in their top secret agents. Carmen (Alexa Vega) and Juni (Daryl Sabara) Cortez are back on another mission, which takes them to a mysterious island where they meet a wildly inventive scientist (Steve Buscemi) and his imaginative creatures, while fighting the forces of rival Spy kids, Gary (Matt O'Leary) and Gerti (Emily Osment) Giggles, as they head right into a trap that will test each and every Cortez spy, from super spies Mom and Dad to their Spy grandparents (Ricardo Montalban, Holland Taylor).