Decorated veteran Will Sharp (Yahya Abdul-Mateen II), in desperate need of $231,00 to cover his wife's medical bills, asks for help from the one person he knows he shouldn’t—his adoptive brother Danny (Jake Gyllenhaal). A dangerous career criminal, Danny instead offers him a score: the biggest bank heist in Los Angeles history: $32 million. With his wife’s survival on the line, Will can’t say no.
But when their getaway takes a turn for the absolute worst, the desperate brothers hijack an ambulance with a wounded cop clinging to life and ace EMT Cam Thompson (Eiza González) onboard. In a high-speed pursuit that never stops, Will and Danny must evade a massive, city-wide law enforcement response, keep their hostages alive, and somehow try not to kill each other, all while executing the most insane escape L.A. has ever seen.