After transplanting his family from Chicago to the Oregon woods for his new job overseeing the construction of a supposedly "eco-friendly" housing development, Dan Sanders (Brendan Fraser) thinks his biggest problem will be helping his city-loving wife Tammy (Brooke Shields) and nature-phobic teenaged son (Matt Prokop) adjust to their new surroundings while pleasing his demanding boss (Ken Jeong). But Dan's troubles have only begun once the local animals discover his leadership role in the destruction of their habitat. He soon lands atop their Most Wanted list, and realizes how much trouble a few feisty forest creatures can cause!
The clever critters bedevil Dan night and day, sabotaging his work, his peace of mindand even his wardrobe. Under this concerted attack, Dan soon finds his onceperfect life in ruins. He completely fails in his efforts to trap, deter or even photograph the animal assault team and without proof of the covert woodland conspiracy against him, no one believes Dan's claims. With his wife and son poised to abandon him, and his construction project in jeopardy, Dan escalates the feud to all-out intra-species war that can only have one winner.