Life couldn't be sweeter for Garfield, everyone's favorite feline. Parked on a comfortable chair in front of the television, feasting on his favorite dish, lasagna, and hurling insults at his beleaguered owner Jon (Breckin Meyer), Garfield is the master of his universe.
When Jon takes Garfield to visit beautiful veterinarian Liz Wilson (Jennifer Love Hewitt), she gives Jon a pepped-up, tail-wagging, panting creature that represents everything that Garfield loathes. Garfield, meet Odie, a lovable, dim-witted... dog. The wise-cracking cat is, for the first time in his nine lives, left speechless. The clueless Odie chases his tail till he's dizzy, crashes into walls, and barks without cause, all to the unbridled delight of Jon who eagerly welcomes Odie into his home.
Odie turns Garfield's perfect world upside down. Garfield's solution: OUT, DARN DOG. When the hapless hound disappears into the evil clutches of local celebrity Happy Chapman (Stephen Tobolowsky), you would think Garfield would rejoice. But he feels responsible for the fate of another. With uncharacteristic energy, courage and selflessness, Garfield manages to pull himself away from his lazy life and spring into action. He's on the unlikeliest of impossible missions: to save Odie.