Married doctors William and Dakota Block (Josh Brolin and Marley Shelton) find their graveyard shift inundated with townspeople ravaged by gangrenous sores and a suspiciously vacant look in their eyes. Among the wounded is Cherry (Rose McGowan), a go-go dancer whose leg was ripped from her body during a roadside attack.
Wray (Freddy Rodriguez), her former significant other, is at her side and watching her back. Cherry may be down, but she hasn't danced her last number.
As the invalids quickly become enraged aggressors, Cherry and Wray lead a team of accidental warriors into the night, hurtling towards a destiny that will leave millions infected, countless dead, and a lucky few struggling to find the last safe corner of Planet Terror.