The story is set in Goa, home to one of the most accomplished magicians of the timeEthan Mascarenhas (Hrithik Roshan). As fate would have had it, Ethan is severely injured when his former best friend who was also a magician betrays him by ruining one of his dangerous magic trick, turning him into a quadriplegic. Confined in his own wheelchair, Ethan's will power only gets stronger and stronger. He becomes the Radio Jockey of an FM Station called Radio Zindagi. His show spreads magic and hope and laughter through his irrepressible wit and humor to every listener and caller, making it difficult to imagine that this is a man who has been immobilised with a spinal injury for the last fourteen years of his life. Sofia D'Souza (Aishwarya Rai), is his elegant nurse who has been accompanying him like a shadow for the past twelve years, leaving her domineering husband. Ethan's life centers on Sofia and they share a silent tacit love which is both beautiful and spirited.