April Burns (Holmes) has never been on good terms with her mother, Joy (Clarkson), but in a burst of goodwill she’s volunteered to host her family for Thanksgiving at the Lower East Side apartment she shares with her boyfriend, Bobby (Luke). As if preparing a holiday feast isn't pressure enough, she discovers her oven is broken and has to search her building for one that works, making appeals to an eclectic array of neighbors.
Meanwhile, the Burns family is speeding down the highway towards New York while recounting April's failures. April's father, Jim (Platt), is determined to have a nice day, but Joy persists in undermining his plans. While perfect daughter Beth (Pill) reminds everyone of her sister's faults and Grandma Dottie (Drummond) can barely remember anyone's name, youngest child Timmy (Gallagher, Jr.) dodges emotional bullets by photographing every awkward moment.