Two best friends, Vince Boudreau (Woody Harrelson) and Caesar Dominguez (Antonio Banderas) are aging boxers who haven't fought in years. Out of the blue they get a chance to work together in Las Vegas. The job promises big bucks but they need them ASAP.
Hitting the road, sparks fly as the two natural competitors anatgonize each other into a frenzy. They pick up a hitchhiker (Lucy Liu), who only throws the situation into further upheaval. When they eventually make it to Vegas, it's time for the big showdown between the two friends.