Genre:  Horror, Sci-Fi/Fantasy, Thriller
Running Time:  104 min.
Release Date: June 4, 2010
DVD: October 12, 2010

Current rating: Rating: 3.18
based on 468 votes and 138 reviews
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Cast: Adrien Brody, Sarah Polley, Delphine Chanéac


Superstar genetic engineers Clive (Adrien Brody) and Elsa (Sarah Polley) specialize in splicing DNA from different animals to create incredible new hybrids. Now they want to use human DNA in a hybrid that could revolutionize science and medicine. But when the pharmaceutical company that funds their research forbids it, Clive and Elsa secretly take their boldest experimentation underground—risking their careers by pushing the boundaries of science to serve their own curiosity and ambition.

The result is Dren, an amazing, strangely beautiful creature of uncommon intelligence and an array of unexpected physical developments.

At first, Dren exceeds their wildest dreams. But as she grows and learns at an accelerated rate, her existence threatens to become their worst nightmare.

  Canadian Connection: Filmed in Ontario, Canada. Several cast members are Canadian.

Director: Vincenzo Natali
Studio: Entertainment One
Producer(s): Steven Hoban
Screenplay: Vincenzo Natali, Antoinette Terry Bryant, Doug Taylor
Official Site: www.splicethefilm.com

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  • 5 stars "Very good movie from Canadian genre filmmaker Vincenzo Natali. Good special effects, especially the way they painted a smile on the face of Sarah Polley, who has never actually smiled in real life."
  • 5 stars "a really good twisted horror flick, that will keep you on the edge of your seat !"
  • 1 star "Finally saw this tonight... I felt sick afterwards.. this movie was messed up !!"