For centuries, two races have evolved hidden deeply within human culture -- the aristocratic, sophisticated Vampires, and the brutal, feral Lycans (werewolves). To humanity, their existence is no more than a whisper of a myth. But to each other, they are lifelong mortal rivals, sworn to wage a secret war until only one race is left standing.
In the midst of this ongoing struggle, a Vampire warrior, Selene (Beckinsale) discovers a Lycan plot to kidnap a young human doctor. After shadowing Michael (Speedman) through the city, she forms an unprecedented bond with him, and when the Lycans make their next move, Selene is there to fend off their vicious assault.
As she races to save Michael and unravel the Lycan intrigue surrounding him, Selene discovers a secret that has terrifying repercussions for both tribes -- a nefarious plan to awaken a new invincible species of predator that combines the strengths of both creatures and the weaknesses of neither, which threatens to tip the balance of power in favor of the werewolves, who have been on the the losing end of the struggle for centuries.