Neil Patrick Harris – Harold & Kumar Go to White Castle (2004)

Picture this: You're driving through a dark, wooded path late at night. You just smoked some wacky tobacky and are trying your hardest to find a White Castle -- where you can finally satisfy your munchies. You see a hitchhiker on the side of the road, and naturally, you pick him up. While you're expecting a smelly drifter with boundary issues, in a hilarious twist of fate, your late night fare turns out to be none other than The Neil Patrick Harris. But this isn't the Doogie Howser, M.D. of '80s yore, this is a Doogie who gets kicked out of parties and trips out on ecstasy.