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In California's San Fernando Valley, Isabel (Nicole Kidman) is trying to reinvent herself. A naive, good-natured witch, she's determined to give up her supernatural powers and lead a "normal" life. At the same time across town, Jack Wyatt (Will Ferrell), a tall, charming actor, is trying to get his career back on track. He sets his sights on an updated version of the beloved 1960s situation comedy Bewitched, reconceived as a starring vehicle for himself in the role of the mere-mortal Darrin.
Fate steps in when Jack accidentally runs into Isabel. He's immediately attracted to her and her nose, which bears an uncanny resemblance to the nose of Elizabeth Montgomery, who played Samantha in the original series. He becomes convinced Isabel could play Samantha in his new series.
Isabel is also taken with Jack, seeing him as the quintessential mortal man with whom she can settle down and lead the normal life she desires.
It turns out they're both right--but in ways neither of them ever imagined.