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A wealthy young man wants to wed a painfully ordinary girl, and a few hours with his family will convince anyone why he's doing so in this black comedy.
Marty Pascal (Josh Hamilton) is engaged to marry Lesly (Tori Spelling), a dizzy blonde he met when she was working at a doughnut shop, and he bravely decides that it's time she met his family, so he brings her along for Thanksgiving dinner at his mother's house in West Virginia.
Bravery is necessary because the Pascals are not an especially healthy or wholesome family. Mother (Genevieve Bujold) explains her philosophy about parenting like so: You raise cattle; children just happen.
In this environment, where refusing your child anything is all but unknown, her youngest son Anthony (Freddie Prinze, Jr.) has grown up to be an overanxious virgin eager to seduce Lesly while Marty's not paying attention.
And Marty's twin sister Jackie (Parker Posey), malignily obsessed with Jacqueline Kennedy Onassis, often re-enacts the murder of JFK using spaghetti sauce for blood (when she can't get ahold of real bullets) and enjoys incestuously seducing Marty (which hardly bothers Mother, who notes that Jackie's hand was holding Marty's penis when they came out the womb).
The House of Yes was based on the play by Wendy MacLeod; first time director Mark S. Waters (brother of screenwriter Daniel Waters) also adapted the screenplay.