The Hollywood actor – who was best known for his work in House of 1000 Corpses and Intolerable Cruelty passed away on Wednesday in Playa del Rey, California, after suffering complications from acromegaly, a rare gland disorder.
The star’s niece, Rene Galarza, announced the sad news on her Facebook page.
She posted: ”It’s with deep sympathy that I’m writing this post. Early this morning my family was informed that our beloved uncle, brother, teammate and friend, Irwin Keyes, has had his last curtain call.
”He is now an angel for us all and will be watching down. Our family wishes to thank all of you who have been a part of his life. He will be missed very much.”
Rob Zombie, who worked with the New York-born actor in House of 1000 Corpses, wrote on Facebook: “I have just heard the terrible news that our friend Irwin Keyes has passed away. Irwin was a cool guy and a big part of the ‘House of 1000 Corpses’ family. He will be missed by us all.”
Irwin – who married Tracy Fontaine since 2008 – most recently filmed an appearance in horror Portend, which will be shown at the FANtastic Horror Film Festival in San Diego in October.