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Chev Chelios (Jason Statham) is about to begin his morning with an unexpected wake-up call. Groggy, practically unable to move and with a heart that's barely beating, he hears the voice of thug Ricky Verona, who reveals Chev has been poisoned in his sleep and only has an hour to live.
As it turns out, Chev is a hit man who freelances for a major West Coast syndicate. A run of the mill job the night before instead went awry: he let his target slip away in an effort to quit professional killing and start a new life with his girlfriend Eve (Amy Smart).
Now, Chev must keep moving to stay alive: the only way to prolong the poison from stopping his heart is to keep his adrenaline flowing. As the clock ticks, Chelios cuts a swath through the streets of Los Angeles, wreaking havoc on those who dare stand in his way. He must rescue Eve from danger, stay two steps ahead of his nemeses and search for an antidote to save his own life.