Born without an immune system, Jimmy Livingston (Gyllenhaal) is forced to live his whole life in a plastic bubble set up in his bedroom. Now a young man, the "Bubble
Boy" discovers the woman he loves (Shelton) is about to get married. He develops a mobile
bubble suite in order set off across the country to Niagra Falls to stop the wedding and win her affections.
During his long trek, he crosses the paths of many strange characters, and must avoid being captured by his over-protective parents.