A group of filmmakers looking for a lost native tribe instead find a man-eating monster in this thriller. Terri Flores (Jennifer Lopez) is a documentary filmmaker on assignment to make a film about the Shirishama Indians of the Amazon, a mysterious tribe known as the People of the Mists.
As Terri and her crew -- cameraman Danny Rich (Ice Cube), sound recordist Gary Dixon (Owen Wilson), anthropologist Steve Cale (Eric Stoltz), production manager Denise Kahlberg (Kari Wuhrer), and host Warren Westridge (Jonathan Hyde) -- head down the river, they discover a man whose boat has sunk and desperately needs rescue.
Paul Sarone (Jon Voight), the mysterious stranger that they save from the waters, claims to know something of the Shirishama and says he will take the crew to them. Instead, he guides the group to the hiding place of the fearsome Anaconda, a gigantic snake that swallows a man whole, vomits him up, and eats him again (no small accomplishment, that).
The snake is worth a fortune if captured, but can a creature so dangerous be captured at all?